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MEK1 Antikörper (pSer221)
MAP2K1
Reaktivität: Human, Maus, Ratte
WB, IHC, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-MEK1 Antikörper
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Target
Alle MEK1 (MAP2K1) Antikörper anzeigen
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Bindungsspezifität
Alle Epitope für MEK1 Antikörper
pSer221
Reaktivität
Alle Reaktivitäten für MEK1 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für MEK1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MEK1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für MEK1 Antikörper
Dieser MEK1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MEK1 Antikörper
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Spezifität
The antibody detects endogenous level of MEK1 only when phosphorylated at serine 221.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pSer221 (A-N-S (p) -F-V) derived from Human MEK1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotyp
IgG
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Discover our top product MAP2K1 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100 Immunofluorescence: 1:100-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Referenzen für anti-MEK1 Antikörper (ABIN362168)
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Ikari, Atomi, Kinjo, Sasaki, Sugatani : "Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. " in: Life sciences , Vol. 86 , Issue 19-20 , pp. 766-73 , (2010 ) (PubMed ).
Details zu MEK1
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Target
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Andere Bezeichnung
MEK1 (MAP2K1 Produkte )
Synonyme
Mek1 antikoerper, CFC3 antikoerper, MAPKK1 antikoerper, MEK1 antikoerper, MKK1 antikoerper, PRKMK1 antikoerper, MEKK1 antikoerper, Prkmk1 antikoerper, mek-2 antikoerper, si:ch211-242m18.2 antikoerper, wu:fj56a12 antikoerper, wu:fj61b01 antikoerper, zgc:56557 antikoerper, ATMEK1 antikoerper, F20B18.180 antikoerper, F20B18_180 antikoerper, MAP kinase/ ERK kinase 1 antikoerper, MITOGEN ACTIVATED PROTEIN KINASE KINASE antikoerper, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antikoerper, NMAPKK antikoerper, MEK antikoerper, mitogen activated protein kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase 1 L homeolog antikoerper, MAP kinase/ ERK kinase 1 antikoerper, Map2k1 antikoerper, MAP2K1 antikoerper, map2k1.L antikoerper, map2k1 antikoerper, MEK1 antikoerper
Hintergrund
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Molekulargewicht
45 kDa
NCBI Accession
NP_002746
UniProt
Q02750
Pathways
MAPK Signalweg , RTK Signalweg , Interferon-gamma Pathway , Fc-epsilon Rezeptor Signalübertragung , Neurotrophin Signalübertragung , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagie , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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