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KIT Antikörper (pTyr721)
KIT
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-KIT Antikörper
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Target
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KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Bindungsspezifität
Alle Epitope für KIT Antikörper
pTyr721
Reaktivität
Alle Reaktivitäten für KIT Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für KIT Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für KIT Antikörper
Polyklonal
Konjugat
Alle Konjugate für KIT Antikörper
Dieser KIT Antikörper ist unkonjugiert
Applikation
Alle Applikationen für KIT Antikörper
Western Blotting (WB)
Spezifität
The antibody detects endogenous level of c-Kit only when phosphorylated at tyrosine 721.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pTyr721 (N-E-Y (p) -M-D) derived from Human c-Kit. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
Western blotting: 1:500-1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Referenzen für anti-KIT Antikörper (ABIN362294)
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Gao, Lin, Gao, Li, Wang, Yu : "MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. " in: Leukemia research , Vol. 35 , Issue 9 , pp. 1226-32 , (2011 ) (PubMed ).
Details zu KIT
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Target
KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Andere Bezeichnung
c-Kit (KIT Produkte )
Synonyme
C-Kit antikoerper, CD117 antikoerper, PBT antikoerper, SCFR antikoerper, Bs antikoerper, Fdc antikoerper, Gsfsco1 antikoerper, Gsfsco5 antikoerper, Gsfsow3 antikoerper, SCO1 antikoerper, SCO5 antikoerper, SOW3 antikoerper, Ssm antikoerper, Tr-kit antikoerper, W antikoerper, c-KIT antikoerper, c-kit antikoerper, MGF antikoerper, KIT antikoerper, C-KIT antikoerper, kit antikoerper, receptor antikoerper, sparse antikoerper, Xkl-1 antikoerper, kit-a antikoerper, kit-b antikoerper, kl1-A antikoerper, krk1 antikoerper, pbt antikoerper, scfr antikoerper, KIT proto-oncogene receptor tyrosine kinase antikoerper, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antikoerper, KIT proto-oncogene receptor tyrosine kinase S homeolog antikoerper, KIT antikoerper, Kit antikoerper, kita antikoerper, kit antikoerper, kit.S antikoerper
Hintergrund
This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
Molekulargewicht
145 kDa
NCBI Accession
NP_000213
UniProt
P10721
Pathways
RTK Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Sensory Perception of Sound , Stem Cell Maintenance , Production of Molecular Mediator of Immune Response , Regulation of long-term Neuronal Synaptic Plasticity
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