The antibody detects endogenous level of total ICAM-1 protein.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Immunogen
Peptide sequence around AA 510-514 (K-K-Y-R-L) derived from Human ICAM-1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Ould-yahoui, Tremblay, Sbai, Ferhat, Bernard, Charrat, Gueye, Lim, Brew, Risso, Dive, Khrestchatisky, Rivera: "A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons." in: PLoS ONE, Vol. 4, Issue 12, pp. e8289, (2009) (PubMed).
Sbai, Ould-Yahoui, Ferhat, Gueye, Bernard, Charrat, Mehanna, Risso, Chauvin, Fenouillet, Rivera, Khrestchatisky: "Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes." in: Glia, Vol. 58, Issue 3, pp. 344-66, (2009) (PubMed).
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.