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Src Antikörper (AA 527-531)
Src
Reaktivität: Human, Maus, Ratte
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Src Antikörper
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Target
Alle Src Antikörper anzeigen
Src
(Proto-oncogene tyrosine-protein kinase Src (Src))
Bindungsspezifität
Alle Epitope für Src Antikörper
AA 527-531
Reaktivität
Alle Reaktivitäten für Src Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für Src Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Src Antikörper
Polyklonal
Konjugat
Alle Konjugate für Src Antikörper
Dieser Src Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Src Antikörper
Western Blotting (WB), Immunohistochemistry (IHC)
Spezifität
The antibody detects endogenous level of total Src protein.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Peptide sequence around AA 527-531 (P-Q-Y-Q-P) derived from Human Src. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotyp
IgG
Top Product
Discover our top product Src Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Referenzen für anti-Src Antikörper (ABIN362786)
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Zheng, Xia, Hawke, Halle, Tremblay, Gao, Zhou, Aldape, Cobb, Xie, He, Lu : "FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. " in: Molecular cell , Vol. 35 , Issue 1 , pp. 11-25 , (2009 ) (PubMed ).
Details zu Src
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Target
Src
(Proto-oncogene tyrosine-protein kinase Src (Src))
Andere Bezeichnung
Src (Src Produkte )
Synonyme
AW259666 antikoerper, pp60c-src antikoerper, C-src1 antikoerper, CG7524 antikoerper, D-Src64B antikoerper, D-src antikoerper, DSRC64 antikoerper, DSrc antikoerper, DSrc64 antikoerper, DSrc64B antikoerper, Dm SRC1 antikoerper, DmHD-358 antikoerper, Dmel\CG7524 antikoerper, Dsrc antikoerper, Dsrc64 antikoerper, Dsrc64B antikoerper, HD-358 antikoerper, MRE5 antikoerper, SRC 64B antikoerper, Src antikoerper, Src1 antikoerper, Src64 antikoerper, c-src antikoerper, dSrc antikoerper, dsrc antikoerper, src antikoerper, src1 antikoerper, src64 antikoerper, src64B antikoerper, src64b antikoerper, ASV antikoerper, SRC1 antikoerper, c-SRC antikoerper, p60-Src antikoerper, c-Src antikoerper, PP60C-SCR antikoerper, SDR antikoerper, SRC proto-oncogene, non-receptor tyrosine kinase antikoerper, uncharacterized LOC5574802 antikoerper, proto-oncogene tyrosine-protein kinase src antikoerper, Rous sarcoma oncogene antikoerper, Src oncogene at 64B antikoerper, SRC antikoerper, LOC5574802 antikoerper, CpipJ_CPIJ010659 antikoerper, Src antikoerper, Src64B antikoerper
Substanzklasse
Viral Protein
Hintergrund
Proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme, phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme.
Molekulargewicht
60 kDa
NCBI Accession
NP_005408
UniProt
P12931
Pathways
JAK-STAT Signalweg , Neurotrophin Signalübertragung , Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Cellular Response to Molecule of Bacterial Origin , Cell-Cell Junction Organization , Regulation of Carbohydrate Metabolic Process , Autophagie , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Smooth Muscle Cell Migration , Negative Regulation of intrinsic apoptotic Signaling , Platelet-derived growth Factor Receptor Signaling , Thromboxane A2 Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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