The antibody detects endogenous level of total c-Cbl protein.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen .
Immunogen
Peptide sequence around AA 698-702 (T-E-Y-M-T) derived from Human c-Cbl. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.