CD86 Antikörper

Produktnummer ABIN371185

Produktdetails anti-CD86 Antikörper

Target: CD86

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD86 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Spezifität: This antibody recognises CD86, the B7-2 costimulatory molecule and a ligand for CD28 and CD152.

Produktmerkmale: Synonyms: CD28LG2, B70, FUN-1, BU63, T-lymphocyte activation antigen CD86, Activation B7-2antigen, CTLA-4 counter-receptor B7.2

Aufreinigung: Purified

Klon: 2D10

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: Identification and enumeration of CD86+ cells. (Ref.1,3,4,9)Immunoprecipitation (Ref.3)Immunohistochemistry on Frozen Sections: Identification of CD86+ cells. (Ref.8,9)In vivo and in vitro blocking assays. (Ref.1,2,8,9)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD86

Target: CD86

Andere Bezeichnung: CD86 (CD86 Produkte)

Hintergrund: CD86, also known as B72, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease. CD86 interacts with HHV8 (KSHV) MIR2 protein.Synonyms: Activation B7-2 antigen, B7.2, B70, BU63, CD28LG2, CTLA-4 counter-receptor B7.2, FUN-1, T-lymphocyte activation antigen CD86

Gen-ID: 12524

UniProt: P42082

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation