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Collagen Type I Antikörper

COL1 Reaktivität: Human, Maus, Säugetier, Fisch, Amphibien, Avian WB, IHC (fro), IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN372599
  • Target Alle Collagen Type I (COL1) Antikörper anzeigen
    Collagen Type I (COL1) (Collagen, Type I (COL1))
    Reaktivität
    • 99
    • 63
    • 58
    • 21
    • 17
    • 17
    • 16
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Säugetier, Fisch, Amphibien, Avian
    Wirt
    • 65
    • 38
    • 14
    Kaninchen
    Klonalität
    • 79
    • 38
    Polyklonal
    Konjugat
    • 57
    • 14
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Dieser Collagen Type I Antikörper ist unkonjugiert
    Applikation
    • 70
    • 48
    • 38
    • 33
    • 30
    • 27
    • 27
    • 27
    • 20
    • 19
    • 16
    • 6
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Spezifität
    Specific for the ~180 kDa Collagen I Alpha-1 Propeptide in Human lung fibroblast extract.
    Kreuzreaktivität (Details)
    Species reactivity (expected):most (if not all) Species of Mammals, Birds, Amphibians and Fishes.
    Species reactivity (tested):Human and Mouse.
    Aufreinigung
    Affinity Chromatography.
    Immunogen
    Peptide from the Human Collagen I Alpha-1 propeptide sequence.
    Isotyp
    IgG
    Top Product
    Discover our top product COL1 Primärantikörper
  • Applikationshinweise
    Western Blot: 1/1000. Immunohistochemitry: 1/100. The antibody also works well for Immunohistochemistry on Paraformaldehyde-FixedSections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90 °C in10 mM sodium citrate ( pH 6.0)/ 0.1 % Tween-20). Note that in Paraffin Sections of Formaldehyde-Fixed fibrotic mouse lung tissue, itrecognizes collagen I molecules that are still associated with the cells in which they weresynthesized.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Liquid in PBS. Contains no preservative
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Marneros: "Effects of chronically increased VEGF-A on the aging heart." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, Issue 3, pp. 1550-1565, (2018) (PubMed).

    Granata, Santoro, Masola, Tomei, Sallustio, Pontrelli, Accetturo, Antonucci, Carratù, Lupo, Zaza: "In Vitro Identification of New Transcriptomic and miRNomic Profiles Associated with Pulmonary Fibrosis Induced by High Doses Everolimus: Looking for New Pathogenetic Markers and Therapeutic Targets." in: International journal of molecular sciences, Vol. 19, Issue 4, (2018) (PubMed).

    Goggins, Kakkad, Mironchik, Jacob, Wildes, Krishnamachary, Bhujwalla: "Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 2, pp. 131-139, (2018) (PubMed).

  • Target
    Collagen Type I (COL1) (Collagen, Type I (COL1))
    Andere Bezeichnung
    Collagen Type I (COL1 Produkte)
    Synonyme
    collagen type III alpha 1 chain antikoerper, COL3A1 antikoerper
    Hintergrund
    Collagen is the most abundant protein in mammals with type 1 collagen being the most abundant of the 29 known collagens. Type 1 collagen is integral in the strengthening and structural support of many tissues including skin, tendon, artery walls, fibrocartilage, bone and teeth. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procoallagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2
    Gen-ID
    1277
    NCBI Accession
    NP_000079
    UniProt
    P02452
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