NMDA 1 Receptor Antikörper (Splice Variant N1)

Produktnummer ABIN372678

Produktdetails anti-NMDA 1 Receptor Antikörper

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Bindungsspezifität: Splice Variant N1

Reaktivität: Human, Ratte, Maus, Hund, Non-Human Primate, Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMDA 1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody recognizes the ~120k NR1 subunit, N1 splice variant insert protein of the NMDA Receptor. It Does not recognize NR1 subunits of the NMDA Receptor that do not contain the N1 insert.

Kreuzreaktivität (Details): Species reactivity (expected):Canine, Chicken, Human, Xenopus and non-Human Primates.
Species reactivity (tested):Mouse and Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Peptide from the NR1 subunit, N1 splice variant insert of Rat NMDA Receptor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1000. Immunohistochemistry on Frozen Sections: 1/1000-1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in 50 μL PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.

Buffer: 5 mM Ammonium Bicarbonate.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu NMDA 1 Receptor

Target: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Andere Bezeichnung: NMDA Receptor 1 (NMDA R1 Produkte)

Synonyme: CG2902 antikoerper, DMNMDAR1 antikoerper, DNMDAR-I antikoerper, DNmdar antikoerper, DmelNmdar1 antikoerper, Dmel\\CG2902 antikoerper, DrNR1 antikoerper, NMDA antikoerper, NMDA R1 antikoerper, NMDAR1 antikoerper, NMdar1 antikoerper, NR1 antikoerper, NRI antikoerper, Nmdar antikoerper, dNR1 antikoerper, dnmdar-I antikoerper, nmr antikoerper, NMDA receptor 1 antikoerper, Nmdar1 antikoerper

Hintergrund: The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1

Gen-ID: 24408

NCBI Accession: NP_058706

UniProt: P35439