SYN1 Antikörper (pSer549)
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- Target Alle SYN1 Antikörper anzeigen
- SYN1 (Synapsin I (SYN1))
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Bindungsspezifität
- pSer549
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Non-Human Primate
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SYN1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)
- Spezifität
- This antibody recognizes the ~78k Synapsin I doublet protein phosphorylated at Ser549. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Human, Bovine, Canine, Mouse and non-Human Primates.
Species reactivity (tested):Rat. - Aufreinigung
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- Immunogen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser549 of Synapsin I.
- Isotyp
- IgG
- Top Product
- Discover our top product SYN1 Primärantikörper
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anti-Synapsin I (SYN1) (AA 362-511) antibody
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anti-Synapsin I (SYN1) (pSer9) antibodySYN1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
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anti-Synapsin I (SYN1) (pSer62), (pSer67) antibodySYN1 Reaktivität: Ratte WB Wirt: Kaninchen Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer549) antibodySYN1 Reaktivität: Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Synapsin I (SYN1) antibodySYN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 113-420) antibodySYN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Western blot: 1/1,000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Target
- SYN1 (Synapsin I (SYN1))
- Andere Bezeichnung
- Synapsin-1 (SYN1 Produkte)
- Hintergrund
- Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.Synonyms: Brain protein 4.1, SYN1, Synapsin I
- Gen-ID
- 6853
- NCBI Accession
- NP_008881
- UniProt
- P17600
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