DBNL Antikörper (N-Term)
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- Target Alle DBNL Antikörper anzeigen
- DBNL (Drebrin-Like (DBNL))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Hund
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Wirt
- Ziege
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Klonalität
- Polyklonal
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Konjugat
- Dieser DBNL Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- AANLSRNGPA LQE-C
- Spezifität
- This antibody is expected to recognise all reported isoforms (NP_054782.2, NP_001014436.1, NP_001116428.1).
- Kreuzreaktivität (Details)
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Species reactivity (expected):Rat, Canine (Dog).
Species reactivity (tested):Human, Mouse. - Aufreinigung
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
- Immunogen
- Peptide from N Terminus of the protein sequence according to NP_054782.2, NP_001014436.1, NP_001116428.1. Genename: DBNL
- Top Product
- Discover our top product DBNL Primärantikörper
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- Applikationshinweise
- Peptide ELISA: Limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 55 kDa band observed in Jurkat and 3T3 lysates (predictedMW of 45 kDa according to NP_054782).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- DBNL (Drebrin-Like (DBNL))
- Andere Bezeichnung
- Drebrin-Like Protein (DBNL) (DBNL Produkte)
- Synonyme
- ABP1 antikoerper, HIP-55 antikoerper, HIP55 antikoerper, SH3P7 antikoerper, Abp1 antikoerper, mAbp1 antikoerper, Sh3p7 antikoerper, abp1 antikoerper, dbnl-B antikoerper, DBNL antikoerper, DKFZp459C0939 antikoerper, drebrin like antikoerper, drebrin-like antikoerper, drebrin like S homeolog antikoerper, drebrin 1 antikoerper, DBNL antikoerper, Dbnl antikoerper, dbnl.S antikoerper, LOC100148204 antikoerper, DBN1 antikoerper
- Hintergrund
- Cellular morphology, adhesion, and motility occur through dynamic reorganization of actin-based superstructures. Actin-binding proteins are critical for regulating actin polymerization and superstructure formation. The Arp2/3 complex is an actin polymerization-inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. Several actin binding proteins, WASP, cortactin, and Abp1, regulate the activity of the Arp2/3 complex. HIP55 is the mammalian homologue of the yeast HIP55, which has been shown to bind actin and to have roles in endocytosis. HIP55 contains a C-terminal Src homology 3 domain and an N-terminal actin depolymerization factor (ADF-H/C) domain that is homologous to a similar domain found in the actin severing protein, cofilin. HIP55 can bind Src kinases, hematopoietic progenitor kinase 1 (HPK-1), myosin I heavy chain kinase, and dynamin. Thus, HIP55 may be important for regulation of the actin cytoskeleton through its ability to interact with F-actin and various other cytoskeletal and cell signaling proteins. There are three different isoforms.Synonyms: CMAP, Cervical mucin-associated protein, Drebrin-F, HIP-55, HPK1-interacting protein of 55 kDa, SH3 domain-containing protein 7, SH3P7
- Molekulargewicht
- 49kDa (NP_054782).
- Gen-ID
- 28988
- NCBI Accession
- NP_054782
- UniProt
- Q9UJU6
- Pathways
- T-Zell Rezeptor Signalweg, Regulation of Actin Filament Polymerization
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