COPS2 Antikörper (C-Term)

Produktnummer ABIN374326

Produktdetails anti-COPS2 Antikörper

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser COPS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequenz: C-LNSLNQAVVS KLA

Spezifität: This antibody detects COPS2/TRIP15 at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Canine (Dog) and Cow.
Species reactivity (tested):Human and Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from C Terminus of the protein sequence according to NP_004227.1, NP_001137359.1. Genename: COPS2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Antibody detection limit dilution 1/16000. Western blot: 1-3 μg/mL. Approx.48 kDa band observed in Human Brain, Mouse Brainlysates and in lysates of Mouse putuitary cell line NIH3T3 (calculated MW of 51.8 kDaaccording to NP_004227.1). Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Thyroid Gland shows nclear and cytoplasm staining inactivated epithelial cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu COPS2

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Andere Bezeichnung: COPS2 / TRIP15 (COPS2 Produkte)

Synonyme: COPS2 antikoerper, ALIEN antikoerper, CSN2 antikoerper, SGN2 antikoerper, TRIP15 antikoerper, wu:fc05f05 antikoerper, wu:fc06g10 antikoerper, wu:fc60f04 antikoerper, wu:fl94f12 antikoerper, zgc:86624 antikoerper, csn2 antikoerper, Tb03.48O8.600 antikoerper, Trip15 antikoerper, AI315723 antikoerper, C85265 antikoerper, Csn2 antikoerper, Sgn2 antikoerper, alien-like antikoerper, ATCSN2 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 12 antikoerper, COP12 antikoerper, FUSCA 12 antikoerper, T20P8.4 antikoerper, T20P8_4 antikoerper, COP9 signalosome subunit 2 antikoerper, COP9 signalosome subunit 2 L homeolog antikoerper, COP9 signalosome complex subunit 2 antikoerper, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antikoerper, proteasome family protein antikoerper, COPS2 antikoerper, cops2 antikoerper, cops2.L antikoerper, Tb927.3.2320 antikoerper, AOR_1_576084 antikoerper, PTRG_07106 antikoerper, LOC100283498 antikoerper, Cops2 antikoerper, csn-2 antikoerper, FUS12 antikoerper

Hintergrund: TRIP15 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP. TRIP15 is also involved in early stage of neuronal differentiation via its interaction with NIF3L1.Synonyms: Alien homolog, COP9 signalosome complex subunit 2, CSN2, JAB1-containing signalosome subunit 2, SGN2, TRIP-15, Thyroid receptor-interacting protein 15

Gen-ID: 9318

NCBI Accession: NP_004227

UniProt: P61201

Pathways: Zellzyklus