FTCD Antikörper (N-Term)

Produktnummer ABIN374453

Produktdetails anti-FTCD Antikörper

Target: FTCD (Formiminotransferase Cyclodeaminase (FTCD))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FTCD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: SQLVECVPNF SEGKNQ

Spezifität: This antibody recognizes 58K Golgi protein at N-term.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Pig.
Species reactivity (tested):Human.

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from the N-Terminus of the protein sequence according to NP_006648.1, NP_996848.1. Genename: FTCD

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Detection Limit: 1/64000. Western blot: 0.03-0.5 μg/mL. Detects a 55-60 kDa band in Human Liver lysate (PredictedMolecular Weight: 58.0 kDa). Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Liver shows distinct staining of membranes and cytoplasm ina selection of hepatocytes.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FTCD

Target: FTCD (Formiminotransferase Cyclodeaminase (FTCD))

Andere Bezeichnung: 58K Golgi Protein (FTCD Produkte)

Hintergrund: 58K Golgi protein antibodies are excellent for use as markers for the Golgi complex. The 58K Golgi protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency, also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.Synonyms: FTCD, Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, Golgi Marker 58K, Golgi marker, LCHC1

Gen-ID: 10841, 9606

UniProt: O95954