STX1A Antikörper (N-Term)

Produktnummer ABIN374595

Produktdetails anti-STX1A Antikörper

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser STX1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: KDRTQELRTA KD-C

Spezifität: Please note this product is expected to recognize the products of 2 different genes STX1A (NP_004594.1and NP_001159375.1) and STX1B (NP_443106.1).

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat, Canine, Bovine.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the N Terminus of the protein sequence according to NP_004594.1, NP_001159375.1, NP_443106.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 0.01 - 0.03 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu STX1A

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Andere Bezeichnung: Syntaxin 1A / STX1A (STX1A Produkte)

Hintergrund: Syntaxin is a 35 kDa type II integral membrane protein localized to the plasma membrane at nerve terminals. Syntaxin was identified through its association with synaptotagmin and N-type calcium channel, a subtype of calcium channel on the plasma membrane important for neurotransmitter release. Homologs of syntaxin were identified in various eukaryotes ranging from yeast to human. Evidences for syntaxin's involvement in vesicular transport and neurotransmission include the requirement of its yeast homologs, SSO 1 and 2, in targeting and fusion of Golgi-derived vesicles with the plasma membrane. Syntaxin is also the target of clostridial neurotoxin C1 that block neurotransmitter release. The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, alpha-SNAP, and NSF.Synonyms: Neuron-specific antigen HPC-1, STX1, STX1B1, STX1B2, Syntaxin-1A, Syntaxin-1B, Syntaxin-1B1, Syntaxin-1B2

Gen-ID: 6804

NCBI Accession: NP_001159375

UniProt: Q16623

Pathways: Peptide Hormone Metabolism, Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport