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Clusterin Antikörper (C-Term)

CLU Reaktivität: Human, Hund WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374606
  • Target Alle Clusterin (CLU) Antikörper anzeigen
    Clusterin (CLU)
    Bindungsspezifität
    • 10
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 90
    • 28
    • 27
    • 12
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Human, Hund
    Wirt
    • 82
    • 40
    • 7
    • 5
    • 2
    • 1
    Ziege
    Klonalität
    • 94
    • 41
    • 1
    Polyklonal
    Konjugat
    • 80
    • 25
    • 17
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Clusterin Antikörper ist unkonjugiert
    Applikation
    • 111
    • 67
    • 57
    • 23
    • 22
    • 19
    • 18
    • 13
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody reacts to Apolipoprotein J (Apo J).
    Kreuzreaktivität (Details)
    Species reactivity (expected):Canine.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography
    Immunogen
    Peptide with sequence C-EKALQEYRKKHREE, from the C Terminus of the protein sequence
    Top Product
    Discover our top product CLU Primärantikörper
  • Applikationshinweise
    Peptide ELISA: 1/32000. Western Blot: 0.3 - 1.0 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Clusterin (CLU)
    Andere Bezeichnung
    Apolipoprotein J (Apo J) (CLU Produkte)
    Hintergrund
    At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individual's relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). Apolipoprotein J is the major secreted product of Sertoli cells and is thought to play a critical role in spermatogenesis. The protein was shown to be a normal constituent of human blood and is also thought to be a control mechanism of the complement cascade. It prevents the binding of a C5b-C7 complex to the membrane of the target cell and in this way inhibits complement-mediated cytolysis. Apolipoprotein J is overexpressed in human prostate and breast cancers and in squamous cell carcinomas. Suppression of Apolipoprotein J renders these cells sensitive to chemotherapeutic drug-mediated apoptosis. It has been proposed that elevated levels of Apolipoprotein J may promote oncogenic transformation and tumor progression by interfering with BAX proapoptotic activities.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
    Gen-ID
    1191, 9606
    UniProt
    P10909
    Pathways
    Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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