PDE11A Antikörper (Internal Region)
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- Target Alle PDE11A Antikörper anzeigen
- PDE11A (phosphodiesterase 11A (PDE11A))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte, Hund
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Wirt
- Ziege
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Klonalität
- Polyklonal
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Konjugat
- Dieser PDE11A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- This antibody reacts to PDE11A.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. - Aufreinigung
- Affinity chromatography
- Immunogen
- Peptide with sequence C-NSFKESMEKSSYSD, from the internal region of the protein sequence
- Top Product
- Discover our top product PDE11A Primärantikörper
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- Applikationshinweise
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Peptide ELISA: 1/2000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PDE11A (phosphodiesterase 11A (PDE11A))
- Andere Bezeichnung
- PDE11A (PDE11A Produkte)
- Synonyme
- PPNAD2 antikoerper, 6330414F14Rik antikoerper, A630086N24Rik antikoerper, Gm350 antikoerper, PDE11A1 antikoerper, si:ch211-222f23.5 antikoerper, PDE11A antikoerper, ppnad2 antikoerper, Pde11a antikoerper, phosphodiesterase 11A antikoerper, phosphodiesterase 11a antikoerper, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antikoerper, PDE11A antikoerper, Pde11a antikoerper, pde11a antikoerper, LOC100470038 antikoerper
- Hintergrund
- One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP, it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.Synonyms: 5'-cyclic-AMP and -GMP phosphodiesterase 11A, Dual 3', PDE11A1, PDE11A2, PDE11A3, PDE11A4, Phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
- Gen-ID
- 50940
- NCBI Accession
- NP_001070664
- UniProt
- Q9HCR9
- Pathways
- cAMP Metabolic Process
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