PRDM2 Antikörper (AA 1-347)

Produktnummer ABIN387783

Produktdetails anti-PRDM2 Antikörper

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Bindungsspezifität: AA 1-347

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRDM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

Klon: 33AT1045

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: CHIP: 1:100. CHIP: 1:100. CHIP: 1:100. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PRDM2 Antikörper (ABIN387783)

Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression." in: Journal of hematology & oncology, Vol. 2, pp. 28, (2009) (PubMed).

Carling, Kim, Yang, Gu, Zhang, Huang: "A histone methyltransferase is required for maximal response to female sex hormones." in: Molecular and cellular biology, Vol. 24, Issue 16, pp. 7032-42, (2004) (PubMed).

Details zu PRDM2

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Andere Bezeichnung: PRDM2 (RIZ1) (PRDM2 Produkte)

Synonyme: MGC114763 antikoerper, prdm2 antikoerper, riz antikoerper, kmt8 antikoerper, riz1 antikoerper, riz2 antikoerper, mtb-zf antikoerper, humhoxy1 antikoerper, PRDM2 antikoerper, HUMHOXY1 antikoerper, KMT8 antikoerper, MTB-ZF antikoerper, RIZ antikoerper, RIZ1 antikoerper, RIZ2 antikoerper, 4833427P12Rik antikoerper, E330024L24Rik antikoerper, Gm1033 antikoerper, Gm19732 antikoerper, Riz antikoerper, Riz1 antikoerper, Znfpr1c1 antikoerper, PR domain containing 2, with ZNF domain S homeolog antikoerper, PR domain containing 2, with ZNF domain b antikoerper, PR domain containing 2, with ZNF domain antikoerper, PR domain zinc finger protein 2 antikoerper, PR/SET domain 2 antikoerper, prdm2.S antikoerper, prdm2b antikoerper, prdm2 antikoerper, LOC100350859 antikoerper, PRDM2 antikoerper, Prdm2 antikoerper

Hintergrund: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 188915

Gen-ID: 7799

NCBI Accession: NP_001007258, NP_001129082, NP_036363, NP_056950

UniProt: Q13029