SOX2 Antikörper

Produktnummer ABIN387798

Produktdetails anti-SOX2 Antikörper

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: SOX2 recombinant protein is used to produce this monoclonal antibody.

Klon: 57CT23-3-4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IF: 1:100. IF: 1:10~50. WB: 1:200~2000. WB: 1:200~2000. WB: 1:1000. WB: 1:4000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-SOX2 Antikörper (ABIN387798)

Chen, Ou, Song, Xian, Ouyang, Xie, Xue, Sun: "Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient." in: Stem cell research, Vol. 23, pp. 57-60, (2018) (PubMed).

Horibe, Hirohashi, Asano, Mariya, Suzuki, Takaya, Saijo, Shionoya, Kubo, Nakatsugawa, Kanaseki, Tsukahara, Watanabe, Atsuyama, Toji, Hirano, Hasegawa, Takahashi, Sato, Torigoe: "Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy." in: PLoS ONE, Vol. 12, Issue 3, pp. e0171460, (2017) (PubMed).

Zheng, Pang, Gu, Gao, Zhang, Pang, Liu: "Melatonin Inhibits Glioblastoma Stem-like cells through Suppression of EZH2-NOTCH1 Signaling Axis." in: International journal of biological sciences, Vol. 13, Issue 2, pp. 245-253, (2017) (PubMed).

Tilson, Haley, Triantafillu, Dozier, Langford, Gillespie, Kim: "ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0132823, (2015) (PubMed).

Details zu SOX2

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Andere Bezeichnung: SOX2 (SOX2 Produkte)

Hintergrund: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Molekulargewicht: 34310

Gen-ID: 6657

NCBI Accession: NP_003097

UniProt: P48431

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis