UBA2 Antikörper (C-Term)

Produktnummer ABIN387913

Produktdetails anti-UBA2 Antikörper

Target: UBA2 (SUMO1 Activating Enzyme Subunit 2 (UBA2))

Bindungsspezifität: AA 601-631, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SAE2 (UBA2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 601-631 amino acids from the C-terminal region of human SAE2 (UBA2).

Klon: RB2822

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu UBA2

Target: UBA2 (SUMO1 Activating Enzyme Subunit 2 (UBA2))

Andere Bezeichnung: SAE2 (UBA2) (UBA2 Produkte)

Synonyme: ATSAE2 antikoerper, EMB2764 antikoerper, EMBRYO DEFECTIVE 2764 antikoerper, F3K23.23 antikoerper, F3K23_23 antikoerper, SUMO-ACTIVATING ENZYME 2 antikoerper, SUMO-activating enzyme 2 antikoerper, ARX antikoerper, SAE2 antikoerper, AA986091 antikoerper, Arx antikoerper, Sae2 antikoerper, UBA1 antikoerper, Ubl1a2 antikoerper, Uble1b antikoerper, sae2 antikoerper, sae2-B antikoerper, uba2-a antikoerper, uba2-b antikoerper, uble1b-B antikoerper, sae2b antikoerper, uble1b antikoerper, wu:fi17g06 antikoerper, zgc:66354 antikoerper, SUMO1 activating enzyme subunit 2 antikoerper, SUMO-activating enzyme 2 antikoerper, ubiquitin like modifier activating enzyme 2 antikoerper, ubiquitin-like modifier activating enzyme 2 antikoerper, ubiquitin like modifier activating enzyme 2 L homeolog antikoerper, MICPUN_63834 antikoerper, MICPUCDRAFT_36729 antikoerper, SAE2 antikoerper, UBA2 antikoerper, Uba2 antikoerper, uba2.L antikoerper, uba2 antikoerper

Hintergrund: Ubiquitin is covalently attached to target proteins by a multienzymatic system consisting of E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-ligating) enzymes. NEDD8, a ubiquitin-like protein, is conjugated to proteins in a manner analogous to ubiquitinylation. beta-amyloid precursor protein-binding protein-1 (APPBP1) can bind to NEDD8 in rabbit reticulocyte lysates. However, since APPBP1 shows similarity to only the N-terminal domain of an E1 enzyme, it must interact with a protein showing similarity to the C-terminal region of E1s. By searching sequence databases, a cDNAs encoding UBA3 was identified as the human homolog of yeast Uba3. The predicted 442-amino acid UBA3 protein shares 43 % sequence identity with yeast Uba3. In vitro, UBA3 formed a complex with APPBP1 and a thioester linkage with NEDD8. APPBP1/UBA3 complex may function as an E1-like enzyme for the activation of NEDD8.

Molekulargewicht: 71224

Gen-ID: 10054

NCBI Accession: NP_005490

UniProt: Q9UBT2