HDAC9 Antikörper (N-Term)

Produktnummer ABIN387960

Produktdetails anti-HDAC9 Antikörper

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Bindungsspezifität: AA 2-32, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: C, M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HDAC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9.

Klon: RB2582

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:1,000. IP: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-HDAC9 Antikörper (ABIN387960)

Salian-Mehta, Xu, McKinsey, Tobet, Wierman: "Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement." in: The Journal of biological chemistry, Vol. 290, Issue 22, pp. 14045-56, (2015) (PubMed).

Sugo, Oshiro, Takemura, Kobayashi, Kohno, Uesaka, Song, Yamamoto: "Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons." in: The European journal of neuroscience, Vol. 31, Issue 9, pp. 1521-32, (2010) (PubMed).

Deng, Ewton, Mercer, Friedman: "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4894-905, (2005) (PubMed).

Details zu HDAC9

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Andere Bezeichnung: HDAC9 (HDAC9 Produkte)

Synonyme: HD7 antikoerper, HD7b antikoerper, HD9 antikoerper, HDAC antikoerper, HDAC7 antikoerper, HDAC7B antikoerper, HDAC9B antikoerper, HDAC9FL antikoerper, HDRP antikoerper, MITR antikoerper, AV022454 antikoerper, D030072B18Rik antikoerper, HD7B antikoerper, Hdac7b antikoerper, Mitr antikoerper, mKIAA0744 antikoerper, hdac9 antikoerper, zgc:73392 antikoerper, TWIST antikoerper, HDAC9 antikoerper, DKFZp459E171 antikoerper, HDA09 antikoerper, HISTONE DEACETYLASE antikoerper, histone deacetylase 9 antikoerper, RGD1310748 antikoerper, RGD1563092 antikoerper, hdac9-A antikoerper, histone deacetylase 9 antikoerper, histone deacetylase 9b antikoerper, histone deacetylase 9 S homeolog antikoerper, HDAC9 antikoerper, Hdac9 antikoerper, hdac9b antikoerper, HDA9 antikoerper, hdac9.S antikoerper

Hintergrund: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Molekulargewicht: 111297

Gen-ID: 9734

NCBI Accession: NP_001191073, NP_001191074, NP_001191075, NP_001191076, NP_001191077, NP_055522, NP_478056, NP_848510, NP_848512

UniProt: Q9UKV0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development