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HDAC10 Antikörper (N-Term)

HDAC10 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB2583 unconjugated
Produktnummer ABIN387962
  • Target Alle HDAC10 Antikörper anzeigen
    HDAC10 (Histone Deacetylase 10 (HDAC10))
    Bindungsspezifität
    • 15
    • 11
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 16-46, N-Term
    Reaktivität
    • 62
    • 32
    • 23
    • 4
    Human
    Wirt
    • 53
    • 9
    Kaninchen
    Klonalität
    • 46
    • 16
    Polyklonal
    Konjugat
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HDAC10 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 28
    • 15
    • 14
    • 13
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HDAC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human HDAC10.
    Klon
    RB2583
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product HDAC10 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).

  • Target
    HDAC10 (Histone Deacetylase 10 (HDAC10))
    Andere Bezeichnung
    HDAC10 (HDAC10 Produkte)
    Synonyme
    HDAC10 antikoerper, wu:fd19e10 antikoerper, zgc:55652 antikoerper, MGC115178 antikoerper, histone deacetylase 10 antikoerper, HD10 antikoerper, AW548891 antikoerper, Hd10 antikoerper, histone deacetylase 10 antikoerper, histone deacetylase 10 L homeolog antikoerper, HDAC10 antikoerper, hdac10 antikoerper, hdac10.L antikoerper, hda10 antikoerper, Hdac10 antikoerper
    Hintergrund
    Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93 % identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDAC8 interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate to convert RUNX1 into a constitutive transcriptional repressor.
    Molekulargewicht
    71445
    Gen-ID
    83933
    NCBI Accession
    NP_001152758, NP_114408
    UniProt
    Q969S8
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