HDAC11 Antikörper (C-Term)

Produktnummer ABIN387965

Produktdetails anti-HDAC11 Antikörper

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Bindungsspezifität: AA 313-345, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.

Klon: RB2589

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-HDAC11 Antikörper (ABIN387965)

Joshi, Greco, Guise, Luo, Yu, Nesvizhskii, Cristea: "The functional interactome landscape of the human histone deacetylase family." in: Molecular systems biology, Vol. 9, pp. 672, (2013) (PubMed).

Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).

Details zu HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Andere Bezeichnung: HDAC11 (HDAC11 Produkte)

Synonyme: CG31119 antikoerper, DHDACX antikoerper, Dmel\\CG31119 antikoerper, HDAC11 antikoerper, HDACX antikoerper, dHDAC11 antikoerper, dmHDA403 antikoerper, zgc:91942 antikoerper, HD11 antikoerper, histone deacetylase 11 antikoerper, Histone deacetylase 11 antikoerper, hypothetical protein antikoerper, HDAC11 antikoerper, hdac11 antikoerper, CpipJ_CPIJ001619 antikoerper, Bm1_15905 antikoerper, LOAG_18214 antikoerper, Hdac11 antikoerper

Hintergrund: HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Molekulargewicht: 39183

Gen-ID: 79885

NCBI Accession: NP_001129513, NP_079103

UniProt: Q96DB2