Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This PIAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 607-637 amino acids from the C-terminal region of human PIAS1.
2900068C24Rik antikoerper, Ddxbp1 antikoerper, GBP antikoerper, DDXBP1 antikoerper, GU/RH-II antikoerper, ZMIZ3 antikoerper, ddxbp1 antikoerper, gbp antikoerper, pias antikoerper, pias1-A antikoerper, xPAIS1 antikoerper, xPIAS1 antikoerper, zmiz3 antikoerper, protein inhibitor of activated STAT 1 antikoerper, protein inhibitor of activated STAT, 1 antikoerper, protein inhibitor of activated STAT, 1a antikoerper, protein inhibitor of activated STAT 1 L homeolog antikoerper, PIAS1 antikoerper, Pias1 antikoerper, pias1a antikoerper, pias1.L antikoerper
Hintergrund
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.