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SUMO4 Antikörper (Mutant, Val55)

SUMO4 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB7264 unconjugated
Produktnummer ABIN388079
  • Target Alle SUMO4 Antikörper anzeigen
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Bindungsspezifität
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Mutant, Val55
    Reaktivität
    • 48
    • 18
    • 18
    Human
    Wirt
    • 45
    • 3
    Kaninchen
    Klonalität
    • 38
    • 10
    Polyklonal
    Konjugat
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser SUMO4 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 23
    • 20
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
    Klon
    RB7264
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Andere Bezeichnung
    SUMO4 (SUMO4 Produkte)
    Synonyme
    IDDM5 antikoerper, SMT3H4 antikoerper, SUMO-4 antikoerper, dJ281H8.4 antikoerper, small ubiquitin-like modifier 4 antikoerper, small ubiquitin-related modifier 4 antikoerper, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antikoerper, SUMO4 antikoerper, sumo4 antikoerper
    Hintergrund
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
    Molekulargewicht
    10685
    Gen-ID
    387082
    NCBI Accession
    NP_001002255
    UniProt
    Q6EEV6
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