ATG16L1 Antikörper (AA 161-190)

Produktnummer ABIN388542

Produktdetails anti-ATG16L1 Antikörper

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Bindungsspezifität: AA 161-190

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG16L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATG16L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from human ATG16L.

Klon: RB07490

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ATG16L1 Antikörper (ABIN388542)

Li, Guo, Yang, Li, Yang, Liu, Liu, Jiang: "1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice." in: Obesity (Silver Spring, Md.), Vol. 25, Issue 3, pp. 561-571, (2017) (PubMed).

Wang, Chen, Yeo, Karsli-Uzunbas, White, Mizushima, Virgin, Guan: "Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide." in: The Journal of cell biology, Vol. 212, Issue 5, pp. 545-60, (2016) (PubMed).

Zhang, Li, Zhang, Zhang, Teves, Liu, Strauss, Pazour, Foster, Hess, Zhang: "Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice." in: Molecular biology of the cell, (2016) (PubMed).

Wu, Zhang, Lu, Xia, Zhou, Petrof, Claud, Chen, Chang, Carmeliet, Sun: "Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis." in: Gut, Vol. 64, Issue 7, pp. 1082-94, (2015) (PubMed).

Wang, Mendonsa, Symington, Zhang, Cadwell, Virgin, Mysorekar: "Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 27, pp. 11008-13, (2012) (PubMed).

Nascimento-Ferreira, Santos-Ferreira, Sousa-Ferreira, Auregan, Onofre, Alves, Dufour, Colomer Gould, Koeppen, Déglon, Pereira de Almeida: "Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease." in: Brain : a journal of neurology, Vol. 134, Issue Pt 5, pp. 1400-15, (2011) (PubMed).

Travassos, Carneiro, Ramjeet, Hussey, Kim, Magalhães, Yuan, Soares, Chea, Le Bourhis, Boneca, Allaoui, Jones, Nuñez, Girardin, Philpott: "Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry." in: Nature immunology, Vol. 11, Issue 1, pp. 55-62, (2009) (PubMed).

Nomura, Uzawa, Yamano, Fushimi, Ishigami, Kouzu, Koike, Siiba, Bukawa, Yokoe, Kubosawa, Tanzawa: "Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis." in: Human pathology, Vol. 40, Issue 1, pp. 83-91, (2008) (PubMed).

Details zu ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Andere Bezeichnung: ATG16L (ATG16L1 Produkte)

Synonyme: APG16L antikoerper, ATG16A antikoerper, ATG16L antikoerper, IBD10 antikoerper, WDR30 antikoerper, 1500009K01Rik antikoerper, Apg16l antikoerper, Atg16l antikoerper, Wdr30 antikoerper, atg16 antikoerper, atg16l antikoerper, fb57e05 antikoerper, wu:fb57e05 antikoerper, zgc:110147 antikoerper, autophagy related 16 like 1 antikoerper, autophagy related 16-like 1 (S. cerevisiae) antikoerper, autophagy related 16-like 1 antikoerper, autophagy related 16 like 1 S homeolog antikoerper, ATG16 autophagy related 16-like 1 (S. cerevisiae) antikoerper, ATG16L1 antikoerper, Atg16l1 antikoerper, atg16l1 antikoerper, atg16l1.S antikoerper

Hintergrund: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.

Molekulargewicht: 68265

Gen-ID: 55054

NCBI Accession: NP_001177195, NP_001177196, NP_060444, NP_110430, NP_942593

UniProt: Q676U5

Pathways: Autophagie