×
Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.
PIK3C3 Antikörper (AA 14-39)
PIK3C3
Reaktivität: Human
WB, IF, IHC (p)
Wirt: Kaninchen
Polyclonal
RB11895
unconjugated
Produktdetails anti-PIK3C3 Antikörper
(ausblenden)
Target
Alle PIK3C3 Antikörper anzeigen
PIK3C3
(Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
Bindungsspezifität
Alle Epitope für PIK3C3 Antikörper
AA 14-39
Reaktivität
Alle Reaktivitäten für PIK3C3 Antikörper
Human
Wirt
Alle Wirte für PIK3C3 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PIK3C3 Antikörper
Polyklonal
Konjugat
Alle Konjugate für PIK3C3 Antikörper
Dieser PIK3C3 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PIK3C3 Antikörper
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
M, Pig, Rat, X
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PI3KC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-39 amino acids from human PI3KC3.
Klon
RB11895
Isotyp
Ig Fraction
Top Product
Discover our top product PIK3C3 Primärantikörper
Alternativen
(anzeigen)
Anwendungsinformationen
(ausblenden)
Applikationshinweise
IF: 1:200. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
(ausblenden)
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Referenzen für anti-PIK3C3 Antikörper (ABIN388594)
(ausblenden)
Minakami, Maehara, Kamakura, Kumano, Miyano, Sumimoto : "Membrane phospholipid metabolism during phagocytosis in human neutrophils. " in: Genes to cells : devoted to molecular & cellular mechanisms , Vol. 15 , Issue 5 , pp. 409-24 , (2010 ) (PubMed ).
Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin : "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. " in: The Journal of biological chemistry , Vol. 285 , Issue 2 , pp. 1371-83 , (2010 ) (PubMed ).
Details zu PIK3C3
(ausblenden)
Target
PIK3C3
(Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
Andere Bezeichnung
PI3KC3 (PIK3C3 Produkte )
Hintergrund
PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
Molekulargewicht
101549
Gen-ID
5289
NCBI Accession
NP_002638
UniProt
Q8NEB9
Pathways
AMPK Signaling , Activation of Innate immune Response , Inositol Metabolic Process , Toll-Like Receptors Cascades , Autophagie
Zuletzt angesehen
(ausblenden)