ACO2 Antikörper (AA 438-467)

Produktnummer ABIN388648

Produktdetails anti-ACO2 Antikörper

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Bindungsspezifität: AA 438-467

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, M, Pig

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ACO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human ACO2.

Klon: RB9338

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ACO2 Antikörper (ABIN388648)

Ruiz, Bégou, Launay, Ranea-Robles, Bianchi, López-Erauskin, Morató, Guilera, Petit, Vaurs-Barriere, Guéret-Gonthier, Bonnet-Dupeyron, Fourcade, Auwerx, Boespflug-Tanguy, Pujol: "Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease." in: Brain pathology (Zurich, Switzerland), (2017) (PubMed).

Navarro, Botella, Metzendorf, Lind, Schneuwly: "Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich?s ataxia." in: Free radical biology & medicine, Vol. 85, pp. 71-82, (2015) (PubMed).

Fernandes, Uytterhoeven, Kuenen, Wang, Slabbaert, Swerts, Kasprowicz, Aerts, Verstreken: "Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration." in: The Journal of cell biology, Vol. 207, Issue 4, pp. 453-62, (2014) (PubMed).

Maity, Bindu, Dey, Goyal, Alam, Pal, Mitra, Bandyopadhyay et al.: "Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel ..." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3058-68, (2009) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." in: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).

Details zu ACO2

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Andere Bezeichnung: ACO2 (ACO2 Produkte)

Hintergrund: ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Molekulargewicht: 85425

Gen-ID: 50

NCBI Accession: NP_001089

UniProt: Q99798