Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
M, Rat
Aufreinigung
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-60 amino acids from the N-terminal region of human BMPR1A.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Peng, Mukhopadhyay, Jarrett, Yoshikawa, Kessler: "BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 48, pp. 17211-24, (2012) (PubMed).
Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).
Mukhopadhyay, McGuire, Peng, Kessler: "Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation." in: Development (Cambridge, England), Vol. 136, Issue 15, pp. 2633-42, (2009) (PubMed).
Target
BMPR1A
(Bone Morphogenetic Protein Receptor 1A (BMPR1A))
10q23del antikoerper, ACVRLK3 antikoerper, ALK3 antikoerper, CD292 antikoerper, SKR5 antikoerper, 1110037I22Rik antikoerper, AU045487 antikoerper, BMPR-IA antikoerper, Bmpr antikoerper, BMPR-1 antikoerper, BRK-1 antikoerper, BMPR1A antikoerper, acvrlk3 antikoerper, alk-3 antikoerper, alk3 antikoerper, cd292 antikoerper, skr5 antikoerper, BR1a antikoerper, alk3tr antikoerper, bmpr1a antikoerper, zgc:136731 antikoerper, wu:fe05b06 antikoerper, wu:fe06e10 antikoerper, zgc:92227 antikoerper, bone morphogenetic protein receptor type 1A antikoerper, bone morphogenetic protein receptor, type 1A antikoerper, bone morphogenetic protein receptor type 1A S homeolog antikoerper, bone morphogenetic protein receptor, type IAa antikoerper, bone morphogenetic protein receptor, type IAb antikoerper, BMPR1A antikoerper, Bmpr1a antikoerper, bmpr1a antikoerper, bmpr1a.S antikoerper, bmpr1aa antikoerper, bmpr1ab antikoerper
Hintergrund
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.