GDF2 Antikörper (N-Term)

Produktnummer ABIN388817

Produktdetails anti-GDF2 Antikörper

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Bindungsspezifität: AA 8-37, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BMP9 (GDF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human BMP9 (GDF2).

Klon: RB2206

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-GDF2 Antikörper (ABIN388817)

Herrera, García-Álvaro, Cruz, Walsh, Fernández, Roncero, Fabregat, Sánchez, Inman: "BMP9 Is a Proliferative and Survival Factor for Human Hepatocellular Carcinoma Cells." in: PLoS ONE, Vol. 8, Issue 7, pp. e69535, (2013) (PubMed).

Herrera, van Dinther, Ten Dijke, Inman: "Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation." in: Cancer research, Vol. 69, Issue 24, pp. 9254-62, (2009) (PubMed).

Details zu GDF2

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Andere Bezeichnung: BMP9 (GDF2) (GDF2 Produkte)

Hintergrund: GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.

Molekulargewicht: 47320

Gen-ID: 2658

NCBI Accession: NP_057288

UniProt: Q9UK05

Pathways: Transition Metal Ion Homeostasis