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USP33 Antikörper (C-Term)

USP33 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB4423-4424 unconjugated
Produktnummer ABIN388945
  • Target Alle USP33 Antikörper anzeigen
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 799-829, C-Term
    Reaktivität
    • 38
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 36
    • 2
    Kaninchen
    Klonalität
    • 36
    • 2
    Polyklonal
    Konjugat
    • 20
    • 4
    • 4
    • 4
    • 3
    • 3
    Dieser USP33 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 21
    • 19
    • 9
    • 6
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    B
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This VDU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 799-829 amino acids from the C-terminal region of human VDU1.
    Klon
    RB4423-4424
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product USP33 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    Andere Bezeichnung
    VDU1 (USP33 Produkte)
    Synonyme
    USP33 antikoerper, VDU1 antikoerper, 9830169D19Rik antikoerper, AA409780 antikoerper, Vdu1 antikoerper, zgc:77308 antikoerper, ubiquitin specific peptidase 33 antikoerper, universal stress protein UspA antikoerper, Usp33 antikoerper, USP33 antikoerper, RR_RS17870 antikoerper, usp33 antikoerper
    Hintergrund
    Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3?-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6
    Molekulargewicht
    106727
    Gen-ID
    23032
    NCBI Accession
    NP_055832, NP_963918, NP_963920
    UniProt
    Q8TEY7
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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