BAP1 Antikörper (C-Term)

Produktnummer ABIN388949

Produktdetails anti-BAP1 Antikörper

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Bindungsspezifität: AA 699-729, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, C, Zf, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-729 amino acids from the C-terminal region of human BAP1.

Klon: RB4428

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Andere Bezeichnung: BAP1 (BAP1 Produkte)

Synonyme: HUCEP-13 antikoerper, UCHL2 antikoerper, BAIAP3 antikoerper, 2300006C11Rik antikoerper, AA989761 antikoerper, AW553466 antikoerper, mKIAA0272 antikoerper, uch-x4 antikoerper, hucep-13 antikoerper, hucep-6 antikoerper, uchl2 antikoerper, si:dkey-42i9.9 antikoerper, BRCA1 associated protein 1 antikoerper, Brca1 associated protein 1 antikoerper, BRCA1 associated protein 1 L homeolog antikoerper, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antikoerper, BAP1 antikoerper, Bap1 antikoerper, bap1.L antikoerper, bap1 antikoerper

Hintergrund: 'BRCA1-associated protein-1,' or BAP1 interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals.. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns.1 BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4.8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21.3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas.1 Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.1

Molekulargewicht: 80362

Gen-ID: 8314

NCBI Accession: NP_004647

UniProt: Q92560