MIB1 Antikörper (N-Term)

Produktnummer ABIN388956

Produktdetails anti-MIB1 Antikörper

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Bindungsspezifität: AA 13-42, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Zf, M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Mib1/Mindbomb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human Mib1/Mindbomb.

Klon: RB4448

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:20~100. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu MIB1

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Andere Bezeichnung: Mib1/Mindbomb (MIB1 Produkte)

Synonyme: DIP-1 antikoerper, DIP1 antikoerper, LVNC7 antikoerper, MIB antikoerper, ZZANK2 antikoerper, ZZZ6 antikoerper, E430019M12Rik antikoerper, Mib antikoerper, mKIAA1323 antikoerper, dip-1 antikoerper, mib antikoerper, mindbomb antikoerper, cg5841 antikoerper, chunp6889 antikoerper, fe47f05 antikoerper, im:7148100 antikoerper, mib1 antikoerper, wu:fe47f05 antikoerper, CG5841 antikoerper, D-mib antikoerper, D-mib1 antikoerper, Dmel\CG5841 antikoerper, Dmib antikoerper, MIB1 antikoerper, Mib1 antikoerper, dmib1 antikoerper, l(3)72CDa antikoerper, l(3)72Db antikoerper, mib1/2 antikoerper, mind-bomb antikoerper, mindbomb E3 ubiquitin protein ligase 1 antikoerper, mindbomb E3 ubiquitin protein ligase 1 L homeolog antikoerper, mind bomb 1 antikoerper, MIB1 antikoerper, Mib1 antikoerper, mib1.L antikoerper, mib1 antikoerper

Hintergrund: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Molekulargewicht: 110136

Gen-ID: 57534

NCBI Accession: NP_065825

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion