ZMPSTE24 Antikörper (AA 400-430)

Produktnummer ABIN389048

Produktdetails anti-ZMPSTE24 Antikörper

Target: ZMPSTE24 (Zmpste24) (Zinc Metalloproteinase, Ste24 (Zmpste24))

Bindungsspezifität: AA 400-430

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZMPSTE24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ZMPSTE24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-430 amino acids from the Central region of human ZMPSTE24.

Klon: RB04772

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ZMPSTE24 Antikörper (ABIN389048)

Akinci, Sankella, Gilpin, Ozono, Garg, Agarwal: "Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide." in: Cold Spring Harbor molecular case studies, Vol. 3, Issue 1, pp. a001339, (2017) (PubMed).

Liu, Wang, Chan, Tjia, Deng, Guan, Huang, Li, Chau, Chen, Pei, Pendas, Cadiñanos, López-Otín, Tse, Hutchison, Chen, Cao, Cheah, Tryggvason, Zhou: "Genomic instability in laminopathy-based premature aging." in: Nature medicine, Vol. 11, Issue 7, pp. 780-5, (2005) (PubMed).

Corrigan, Kuszczak, Rusinol, Thewke, Hrycyna, Michaelis, Sinensky: "Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24." in: The Biochemical journal, Vol. 387, Issue Pt 1, pp. 129-38, (2005) (PubMed).

Details zu ZMPSTE24

Target: ZMPSTE24 (Zmpste24) (Zinc Metalloproteinase, Ste24 (Zmpste24))

Andere Bezeichnung: ZMPSTE24 (Zmpste24 Produkte)

Synonyme: DDBDRAFT_0189115 antikoerper, DDBDRAFT_0237846 antikoerper, DDB_0189115 antikoerper, DDB_0237846 antikoerper, F2N1.21 antikoerper, F2N1_21 antikoerper, STE24 antikoerper, FACE-1 antikoerper, FACE1 antikoerper, HGPS antikoerper, PRO1 antikoerper, Ste24p antikoerper, A530043O15Rik antikoerper, D030046F19 antikoerper, Face-1 antikoerper, MADB antikoerper, fi45a02 antikoerper, wu:fi45a02 antikoerper, zgc:55655 antikoerper, zinc metallopeptidase STE24 antikoerper, zinc metallopeptidase STE24 L homeolog antikoerper, CAAX prenyl protease antikoerper, Peptidase family M48 family protein antikoerper, zinc metallopeptidase, STE24 antikoerper, zinc metallopeptidase, STE24 homolog antikoerper, ZMPSTE24 antikoerper, zmpste24.L antikoerper, zmpste24 antikoerper, ATSTE24 antikoerper, Zmpste24 antikoerper

Hintergrund: ZMPSTE24 is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.

Molekulargewicht: 54813

Gen-ID: 10269

NCBI Accession: NP_005848

UniProt: O75844