PAPSS1 Antikörper (C-Term)

Produktnummer ABIN389138

Produktdetails anti-PAPSS1 Antikörper

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Bindungsspezifität: AA 592-624, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAPSS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.

Klon: RB5109

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PAPSS1 Antikörper (ABIN389138)

Bergelin, Blom, Heikkilä, Löf, Alam, Balthasar, Slotte, Hinkkanen, Törnquist: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." in: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).

Details zu PAPSS1

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Andere Bezeichnung: PAPSS1 (PAPSS1 Produkte)

Synonyme: ATPSK1 antikoerper, PAPSS antikoerper, SK1 antikoerper, AI325286 antikoerper, Asapk antikoerper, papss1 antikoerper, MGC82588 antikoerper, atpsk1 antikoerper, papss antikoerper, sk1 antikoerper, PAPSS1 antikoerper, wu:fc43e12 antikoerper, zgc:194984 antikoerper, zgc:194985 antikoerper, CG8363 antikoerper, DmPAPSS antikoerper, Dmel\\CG8363 antikoerper, PAPS antikoerper, Paps antikoerper, l(3)76BDn antikoerper, paps antikoerper, 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antikoerper, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antikoerper, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antikoerper, PAPS synthetase antikoerper, PAPSS1 antikoerper, Papss1 antikoerper, papss1 antikoerper, papss1.L antikoerper, LOC100543301 antikoerper, LOC100637112 antikoerper, Papss antikoerper

Hintergrund: Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

Molekulargewicht: 70833

Gen-ID: 9061

NCBI Accession: NP_005434

UniProt: O43252

Pathways: Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process