This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This SULT4A1a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SULT4A1a/b.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure(number and length of exons) is similar among family members. SULT4A1 isoforms a and b are selectively expressed in brain tissue. Isoform a is the predominant of the two isoforms of this protein. Isoform b includes an alternate segment, compared to isoform a, that causes a frameshift. The resulting protein (isoform b) has a distinct and shorter C-terminus when compared to isoform a.