Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
M
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This COL9A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-456 amino acids from the Central region of human COL9A1.
cb339 antikoerper, sb:cb339 antikoerper, zgc:85892 antikoerper, wu:fa12a12 antikoerper, wu:fa12d02 antikoerper, wu:fc22c08 antikoerper, wu:fc38d08 antikoerper, edm6 antikoerper, MGC82441 antikoerper, DJ149L1.1.2 antikoerper, EDM6 antikoerper, MED antikoerper, STL4 antikoerper, Col9a-1 antikoerper, collagen, type IX, alpha 1b antikoerper, collagen, type IX, alpha 1 L homeolog antikoerper, collagen type IX alpha 1 chain antikoerper, collagen, type IX, alpha 1 antikoerper, collagen alpha-1(IX) chain antikoerper, col9a1b antikoerper, col9a1.L antikoerper, COL9A1 antikoerper, Col9a1 antikoerper, LOC101102992 antikoerper
Hintergrund
COL9A1 is one of the three alpha chains of type IX collagen, which is a minor (5-20 % ) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule,and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in the COL9A1 gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects.