ERBB4 Antikörper (pTyr1162)

Produktnummer ABIN389572

Produktdetails anti-ERBB4 Antikörper

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Bindungsspezifität: pTyr1162

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERBB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HER4 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1162 of human HER4.

Klon: RB5687

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:500. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ERBB4 Antikörper (ABIN389572)

Prickett, Agrawal, Wei, Yates, Lin, Wunderlich, Cronin, Cruz, Rosenberg, Samuels: "Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4." in: Nature genetics, Vol. 41, Issue 10, pp. 1127-32, (2009) (PubMed).

Burns, Li, Cheney, Ou, Franlin-Pfeifer, Kuklin, Zhang: "Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 57, Issue 3, pp. 257-64, (2009) (PubMed).

Details zu ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Andere Bezeichnung: HER4 (ERBB4 Produkte)

Synonyme: erbb4 antikoerper, si:ch211-227n20.1 antikoerper, Her4 antikoerper, c-erbB-4 antikoerper, HER4 antikoerper, p180erbB4 antikoerper, erb-b2 receptor tyrosine kinase 4 antikoerper, erb-b2 receptor tyrosine kinase 4a antikoerper, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antikoerper, erb-b2 receptor tyrosine kinase 4 L homeolog antikoerper, receptor tyrosine-protein kinase ErbB-4 antikoerper, ERBB4 antikoerper, erbb4a antikoerper, erbb4 antikoerper, erbb4.L antikoerper, Tsp_13582 antikoerper, Erbb4 antikoerper

Hintergrund: HER4/ERBB4 is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. It is a receptor for NDF/heregulin.

Molekulargewicht: 146808

Gen-ID: 2066

NCBI Accession: NP_001036064, NP_005226

UniProt: Q15303

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung