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MEK1 Antikörper (pSer218, pSer222)

Name: MEK1 Antikörper (pSer218, pSer222)
SKU: ABIN389590
Price: 467.5 EUR
Availability: InStock

MAP2K1 Reaktivität: Human WB, IHC (p), DB Wirt: Kaninchen Polyclonal RB05985 unconjugated

Western blot analysis of lysates from Hela cell line, untreated or treated with T(200nM, 30 min), using Bi-Phospho-MEK1(/222) Antibody (upper) or GDH (lower). (MEK1 Antikörper (pSer218, pSer222))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (MEK1 Antikörper (pSer218, pSer222))

IHC (p)

Dot blot analysis of anti-Phospho-MEK1 Pab (ABIN389590 and ABIN2839607) on nitrocellulose membrane. (MEK1 Antikörper (pSer218, pSer222))

3 Abbildungen

Produktnummer ABIN389590

Datenblatt (PDF)

Target Alle MEK1 (MAP2K1) Antikörper anzeigen

MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Bindungsspezifität
38

27

24

21

21

18

16

16

15

13

10

10

9

8

8

8

6

6

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
pSer218, pSer222
Reaktivität
332

188

182

34

29

17

12

11

11

10

7

5

5

4

2

1

1

1

1
Human
Wirt
300

29

3

2

2
Kaninchen
Passende Sekundärantikörper
Klonalität
265

71
Polyklonal
Konjugat
169

19

13

11

11

10

8

8

8

8

8

5

5

5

5

5

5

5

5

5

5

5

4

2

2
Dieser MEK1 Antikörper ist unkonjugiert
Applikation
206

104

77

68

66

49

29

23

22

15

12

9

7

7

3

3

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Homologie

D, E, Ha, M, Rb, Rat, X, C

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This MEK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S218/222 of human MEK1.

Klon

RB05985

Isotyp

Ig Fraction

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Applikationshinweise

WB: 1:500. IHC-P: 1:50~100. DB: 1:500

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Target

MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Andere Bezeichnung

MEK1 (MAP2K1 Produkte)

Hintergrund

MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

Molekulargewicht

43439

Gen-ID

5604

NCBI Accession

NP_002746

UniProt

Q02750

Pathways

MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling