YES1/SRC (pTyr530) Antikörper

Produktnummer ABIN389661

Produktdetails

Target: YES1/SRC

Bindungsspezifität: pTyr530

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: C, Zf, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SRC Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y530 of human SRC.

Klon: RB05974

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen

Miller, Morton, Pinese, Saturno, Jamieson, McGhee, Timpson, Leach, McGarry, Shanks, Bailey, Chang, Oien, Karim, Au, Steele, Carter, McKay, Anderson, Evans, Marais, Springer, Biankin, Erler, Sansom: "Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy." in: EMBO molecular medicine, Vol. 7, Issue 8, pp. 1063-76, (2015) (PubMed).

Varrin-Doyer, Vincent, Cavagna, Auvergnon, Noraz, Rogemond, Honnorat, Moradi-Améli, Giraudon: "Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration." in: The Journal of biological chemistry, Vol. 284, Issue 19, pp. 13265-76, (2009) (PubMed).

Antigendetails

Target: YES1/SRC

Hintergrund: This protein has tyrosine kinase activity and belongs to the src family of proteins. The YES1 gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene.

Gen-ID: 6714

NCBI Accession: NP_005408, NP_938033

UniProt: P12931, P07947