This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RGS19 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S24 of human RGS19.
RGS19 antikoerper, GAIP antikoerper, RGSGAIP antikoerper, 2610042F04Rik antikoerper, AI324841 antikoerper, AW547781 antikoerper, Camki antikoerper, Gaip antikoerper, regulator of G protein signaling 19 antikoerper, regulator of G-protein signaling 19 antikoerper, RGS19 antikoerper, Rgs19 antikoerper
Hintergrund
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.