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MECP2 Antikörper (pSer80)

MECP2 Reaktivität: Human DB Wirt: Kaninchen Polyclonal RB27934 unconjugated
Produktnummer ABIN389978
  • Target Alle MECP2 Antikörper anzeigen
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Bindungsspezifität
    • 19
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer80
    Reaktivität
    • 101
    • 40
    • 31
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Wirt
    • 100
    • 7
    • 1
    Kaninchen
    Klonalität
    • 101
    • 7
    Polyklonal
    Konjugat
    • 62
    • 10
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MECP2 Antikörper ist unkonjugiert
    Applikation
    • 80
    • 64
    • 36
    • 30
    • 12
    • 9
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Dot Blot (DB)
    Homologie
    Pr, M, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MeCP2.
    Klon
    RB27934
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MECP2 Primärantikörper
  • Applikationshinweise
    DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Liu, Ni, Sun: "Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development." in: Neuroscience bulletin, Vol. 33, Issue 1, pp. 1-16, (2017) (PubMed).

  • Target
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Andere Bezeichnung
    MeCP2 (MECP2 Produkte)
    Synonyme
    AUTSX3 antikoerper, MRX16 antikoerper, MRX79 antikoerper, MRXS13 antikoerper, MRXSL antikoerper, PPMX antikoerper, RS antikoerper, RTS antikoerper, RTT antikoerper, 1500041B07Rik antikoerper, BB130002 antikoerper, D630021H01Rik antikoerper, Mbd5 antikoerper, WBP10 antikoerper, wu:fk96a04 antikoerper, zgc:111857 antikoerper, methyl-CpG binding protein 2 antikoerper, methyl CpG binding protein 2 antikoerper, methyl-CpG binding protein 2 S homeolog antikoerper, MECP2 antikoerper, Mecp2 antikoerper, mecp2 antikoerper, mecp2.S antikoerper
    Hintergrund
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
    Molekulargewicht
    52441
    Gen-ID
    4204
    NCBI Accession
    NP_001104262, NP_004983
    UniProt
    P51608
    Pathways
    Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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