TBK (pSer172) Antikörper

Produktnummer ABIN390010

Produktdetails

Target: TBK

Bindungsspezifität: pSer172

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Dot Blot (DB)

Homologie: Zf, M, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.

Klon: RB16573

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen

Muvaffak, Pan, Yan, Fernandez, Lim, Dolinski, Nguyen, Strack, Wu, Chung, Zhang, Hulton, Ripley, Hirsch, Nagashima, Wong, Jánne, Seidel-Dugan, Zawel, Kirschmeier, Middleton, Morris, Wang: "Evaluating TBK1 as a therapeutic target in cancers with activated IRF3." in: Molecular cancer research : MCR, Vol. 12, Issue 7, pp. 1055-66, (2014) (PubMed).

Antigendetails

Target: TBK

Hintergrund: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Molekulargewicht: 83642

Gen-ID: 29110

NCBI Accession: NP_037386

UniProt: Q9UHD2