BIRC3 Antikörper (N-Term)

Produktnummer ABIN390069

Produktdetails anti-BIRC3 Antikörper

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Bindungsspezifität: AA 101-131, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This cIAP2 (BIRC3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human cIAP2 (BIRC3).

Klon: RB2213

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-BIRC3 Antikörper (ABIN390069)

Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." in: Journal of bioenergetics and biomembranes, (2015) (PubMed).

Details zu BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Andere Bezeichnung: cIAP2 (BIRC3) (BIRC3 Produkte)

Synonyme: AIP1 antikoerper, API2 antikoerper, CIAP2 antikoerper, HAIP1 antikoerper, HIAP1 antikoerper, MALT2 antikoerper, MIHC antikoerper, RNF49 antikoerper, c-IAP2 antikoerper, Api1 antikoerper, Api2 antikoerper, IAP1 antikoerper, IAP2 antikoerper, MIHB antikoerper, Birc2 antikoerper, HIAP2 antikoerper, MIAP1 antikoerper, MIAP2 antikoerper, cIAP1 antikoerper, cIAP2 antikoerper, cIAP-1 antikoerper, cIAP-2 antikoerper, AW107670 antikoerper, BIRC2 antikoerper, baculoviral IAP repeat containing 3 antikoerper, baculoviral IAP repeat-containing 3 antikoerper, baculoviral IAP repeat-containing protein 3 antikoerper, inhibitor of apoptosis protein-2 antikoerper, BIRC3 antikoerper, Birc3 antikoerper, LOC100399118 antikoerper, OpmnVgp074 antikoerper

Hintergrund: BIRC3 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.

Molekulargewicht: 68372

Gen-ID: 330

NCBI Accession: NP_001156, NP_892007

UniProt: Q13489

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades