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MLLT10 Antikörper (C-Term)

MLLT10 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB1930 unconjugated
Produktnummer ABIN390125
  • Target Alle MLLT10 Antikörper anzeigen
    MLLT10 (Protein AF-10 (MLLT10))
    Bindungsspezifität
    • 16
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 998-1027, C-Term
    Reaktivität
    • 48
    • 19
    • 13
    Human
    Wirt
    • 46
    • 3
    • 1
    Kaninchen
    Klonalität
    • 47
    • 3
    Polyklonal
    Konjugat
    • 20
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLLT10 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 19
    • 14
    • 14
    • 6
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MLLT10 (AF10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1027 amino acids from the C-terminal region of human MLLT10 (AF10).
    Klon
    RB1930
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MLLT10 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    MLLT10 (Protein AF-10 (MLLT10))
    Andere Bezeichnung
    MLLT10 (AF10) (MLLT10 Produkte)
    Synonyme
    AF10 antikoerper, Af10 antikoerper, B130021D15Rik antikoerper, D630001B22Rik antikoerper, mKIAA4140 antikoerper, MLLT10, histone lysine methyltransferase DOT1L cofactor antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 antikoerper, MLLT10 antikoerper, Mllt10 antikoerper
    Hintergrund
    Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.
    Molekulargewicht
    113320
    Gen-ID
    8028
    NCBI Accession
    NP_001182555, NP_001182556, NP_001182557, NP_001182559, NP_004632
    UniProt
    P55197
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