OAS3 Antikörper (C-Term)

Produktnummer ABIN390166

Produktdetails anti-OAS3 Antikörper

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Bindungsspezifität: AA 1056-1087, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3.

Klon: RB1945

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-OAS3 Antikörper (ABIN390166)

Ibsen, Gad, Thavachelvam, Boesen, Desprès, Hartmann: "The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation." in: Journal of virology, Vol. 88, Issue 24, pp. 14222-31, (2014) (PubMed).

Details zu OAS3

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Andere Bezeichnung: OAS3 (OAS3 Produkte)

Synonyme: p100 antikoerper, Oasl10 antikoerper, 2'-5'-oligoadenylate synthetase 3 antikoerper, 2'-5' oligoadenylate synthetase 3 antikoerper, OAS3 antikoerper, Oas3 antikoerper

Hintergrund: OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Molekulargewicht: 121170

Gen-ID: 4940

NCBI Accession: NP_006178

UniProt: Q9Y6K5

Pathways: Hepatitis C