Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.

Presenilin 1 Antikörper (C-Term)

Name: Presenilin 1 Antikörper (C-Term)
SKU: ABIN390169
Price: 445.5 EUR
Availability: InStock

PSEN1 Reaktivität: Human, Maus WB, IHC (p), FACS, IF Wirt: Kaninchen Polyclonal RB2257 unconjugated

All lanes : Anti-PSEN1 Antibody (C-term) at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 μg per lane. (Presenilin 1 Antikörper (C-Term))

Presenilin 1 (PSEN1) Antibody (C-term) (ABIN390169 and ABIN2840665) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). (Presenilin 1 Antikörper (C-Term))

FACS

Confocal immunofluorescent analysis of Presenilin 1 (PSEN1) Antibody (C-term) (ABIN390169 and ABIN2840665) with MDA-M cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Presenilin 1 Antikörper (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Presenilin 1 Antikörper (C-Term))

IHC (p)

4 Abbildungen

(1 reference)

Produktnummer ABIN390169

Datenblatt (PDF)

Target Alle Presenilin 1 (PSEN1) Antikörper anzeigen

Presenilin 1 (PSEN1)
Bindungsspezifität
31

15

15

9

7

7

7

6

5

5

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 330-359, C-Term
Reaktivität
111

90

60

9

9

8

6

4

3

3

2

1

1

1

1
Human, Maus
Wirt
98

36

2

2

2

1
Kaninchen
Passende Sekundärantikörper
Klonalität
134

7
Polyklonal
Konjugat
50

11

10

7

4

4

4

4

4

4

4

4

4

4

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Dieser Presenilin 1 Antikörper ist unkonjugiert
Applikation
108

54

52

52

42

17

14

13

10

6

3

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Homologie

Pr, Rat

Aufreinigung

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1).

Klon

RB2257

Isotyp

Ig Fraction

Top Product

Discover our top product PSEN1 Primärantikörper
anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 4-218) antibody
PSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (Middle Region) antibody
PSEN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (FITC)
PSEN1 Reaktivität: Human, Maus WB, IHC Wirt: Kaninchen Polyclonal FITC

anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (Alkaline Phosphatase (AP))
PSEN1 Reaktivität: Human, Maus WB, IHC Wirt: Kaninchen Polyclonal Alkaline Phosphatase (AP)

anti-Presenilin 1 (PSEN1) (AA 100-200) antibody (Biotin)
PSEN1 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal Biotin

anti-Presenilin 1 (PSEN1) (AA 100-200) antibody (PE)
PSEN1 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal PE

anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (APC)
PSEN1 Reaktivität: Human, Maus WB, IHC Wirt: Kaninchen Polyclonal APC

anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (HRP)
PSEN1 Reaktivität: Human, Maus WB, IHC Wirt: Kaninchen Polyclonal HRP

Applikationshinweise

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
Target

Presenilin 1 (PSEN1)

Abstract

PSEN1 Produkte

Synonyme

pre1 antikoerper, psen antikoerper, zfPS1 antikoerper, zf-PS1 antikoerper, ad3 antikoerper, fad antikoerper, ps1 antikoerper, s182 antikoerper, X-PS-beta antikoerper, X-PS-alpha antikoerper, AD3 antikoerper, FAD antikoerper, PS-1 antikoerper, PS1 antikoerper, S182 antikoerper, Ad3h antikoerper, presenilin 1 antikoerper, presenilin 1 L homeolog antikoerper, psen1 antikoerper, PSEN1 antikoerper, Psen1 antikoerper, psen1.L antikoerper

Hintergrund

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

Molekulargewicht

52668

Gen-ID

5663

NCBI Accession

NP_000012, NP_015557

UniProt

P49768

Pathways

Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport