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WISP1 Antikörper (AA 171-200)

WISP1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB2115-2116 unconjugated
Produktnummer ABIN390187
  • Target Alle WISP1 Antikörper anzeigen
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Bindungsspezifität
    • 15
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-200
    Reaktivität
    • 40
    • 26
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 54
    • 5
    • 1
    • 1
    Kaninchen
    Klonalität
    • 57
    • 4
    Polyklonal
    Konjugat
    • 26
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WISP1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 21
    • 20
    • 13
    • 13
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This WISP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human WISP1.
    Klon
    RB2115-2116
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product WISP1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Ji, Jia, Jia, Ji, Hargest, Jiang: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).

  • Target
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Andere Bezeichnung
    WISP1 (WISP1 Produkte)
    Synonyme
    CCN4 antikoerper, WISP1c antikoerper, WISP1i antikoerper, WISP1tc antikoerper, WISP-1 antikoerper, WISP1 antikoerper, si:ch211-38f10.2 antikoerper, AW146261 antikoerper, Elm1 antikoerper, zgc:172276 antikoerper, WNT1 inducible signaling pathway protein 1 antikoerper, WNT1 inducible signaling pathway protein 1a antikoerper, WNT1-inducible-signaling pathway protein 1-like antikoerper, WNT1 inducible signaling pathway protein 1b antikoerper, WISP1 antikoerper, wisp1a antikoerper, Wisp1 antikoerper, LOC100627044 antikoerper, wisp1b antikoerper
    Hintergrund
    Wisp1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. Wisp1 may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level.
    Molekulargewicht
    40331
    Gen-ID
    8840
    NCBI Accession
    NP_001191798, NP_001191799, NP_003873, NP_543028
    UniProt
    O95388
    Pathways
    WNT Signalweg, Growth Factor Binding
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