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Sclerostin Antikörper (N-Term)

Name: Sclerostin Antikörper (N-Term)
SKU: ABIN390193
Price: 445.5 EUR
Availability: InStock

SOST Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal RB12388 unconjugated

Western blot analysis of lysates from mouse liver, mouse lung, rat kidney tissue lysate (from left to right), using SOST Antibody (N-term) (ABIN390193 and ABIN2840682). (Sclerostin Antikörper (N-Term))

Immunohistochemical analysis of paraffin-embedded Human kidney tissue using A performed on the Leica® BOND RXm. (Sclerostin Antikörper (N-Term))

IHC (p)

All lanes : Anti-SOST Antibody (N-term) at 1:2000 dilution Lane 1: mouse lung lysates Lane 2: human liver lysates Lane 3: Hela whole cell lysates Lysates/proteins at 20 μg per lane. (Sclerostin Antikörper (N-Term))

All lanes : Anti-SOST Antibody (N-term) at 1:1000 dilution Lane 1: human kidney lysates Lane 2: human liver lysates Lysates/proteins at 20 μg per lane. (Sclerostin Antikörper (N-Term))

Anti-SOST Antibody (N-term) at 1:2000 dilution + Recombinant human SOST protein lysate Lysates/proteins at 20 ng per lane. (Sclerostin Antikörper (N-Term))

5 Abbildungen

(2 Referenzen)

Produktnummer ABIN390193

Datenblatt (PDF)

Target Alle Sclerostin (SOST) Antikörper anzeigen

Sclerostin (SOST)
Bindungsspezifität
15

9

8

7

3

3

2

2

1

1

1

1

1

1

1
AA 12-42, N-Term
Reaktivität
67

50

34

16

15

15

2

1

1

1

1
Human, Maus, Ratte
Wirt
69

3

2

1
Kaninchen
Passende Sekundärantikörper
Klonalität
70

5
Polyklonal
Konjugat
26

6

6

5

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
Dieser Sclerostin Antikörper ist unkonjugiert
Applikation
67

29

24

22

13

10

5

4

3

2

2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie

B

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SOST.

Klon

RB12388

Isotyp

IgG
anti-Sclerostin (SOST) (AA 25-213) antibody
SOST Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 24-213) antibody
SOST Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 24-213) antibody
SOST Reaktivität: Human IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 121-180) antibody
SOST Reaktivität: Human, Maus, Ratte, Kaninchen WB, ELISA, IF (p), ICC, IHC (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 134-163) antibody
SOST Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB13011 unconjugated

anti-Sclerostin (SOST) (AA 38-66), (N-Term) antibody
SOST Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB36187 unconjugated

anti-Sclerostin (SOST) (N-Term) antibody
SOST Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 25-209) antibody
SOST Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 38-87) antibody
SOST Reaktivität: Human, Hund, Schwein, Pferd, Fledermaus, Affe WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Sclerostin (SOST) (C-Term) antibody
Verified SOST Reaktivität: Human IHC, ELISA Wirt: Ziege Polyclonal unconjugated

Applikationshinweise

WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:2000. IHC-P-Leica: 1:500

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid freeze-thaw cycles.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit

6 months
Zarei, Hulley, Sabokbar, Javaid: "Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips." in: Calcified tissue international, Vol. 100, Issue 6, pp. 609-618, (2018) (PubMed).

Lin, Lin, Chang, Wang, Lai: "Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation." in: Bioelectromagnetics, Vol. 36, Issue 7, pp. 494-505, (2015) (PubMed).
Target

Sclerostin (SOST)

Andere Bezeichnung

SOST (SOST Produkte)

Synonyme

LOC100313724 antikoerper, CDD antikoerper, VBCH antikoerper, 5430411E23Rik antikoerper, sclerostin antikoerper, LOC100313724 antikoerper, SOST antikoerper, Sost antikoerper

Hintergrund

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Molekulargewicht

24031

Gen-ID

50964

NCBI Accession

NP_079513

UniProt

Q9BQB4