CDC25A Antikörper (AA 271-300)

Produktnummer ABIN390214

Produktdetails anti-CDC25A Antikörper

Target: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Bindungsspezifität: AA 271-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC25A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Cdc25A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human Cdc25A.

Klon: RB07640

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CDC25A Antikörper (ABIN390214)

Wang, Ding, Liu, Li, Wei, Yu, Liu, Ying, Gao, Jiang, Wang: "A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk." in: Oncogene, (2015) (PubMed).

Details zu CDC25A

Target: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Andere Bezeichnung: Cdc25A (CDC25A Produkte)

Synonyme: cdc25a2 antikoerper, cdc25A antikoerper, sb:cb317 antikoerper, CDC25A2 antikoerper, D9Ertd393e antikoerper, cell division cycle 25A antikoerper, cell division cycle 25B antikoerper, cell division cycle 25A S homeolog antikoerper, CDC25A antikoerper, cdc25a antikoerper, cdc25b antikoerper, Cdc25a antikoerper, cdc25a.S antikoerper

Hintergrund: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.

Molekulargewicht: 59087

Gen-ID: 993

NCBI Accession: NP_001780, NP_963861

UniProt: P30304

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase