PINK1 Antikörper (N-Term)

Produktnummer ABIN390369

Produktdetails anti-PINK1 Antikörper

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Bindungsspezifität: AA 118-147, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).

Klon: RB07381

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PINK1 Antikörper (ABIN390369)

Wang, Hu, Zou, Xiang, Jiang, Botchway, Huo, Du, Fang: "The post-therapeutic effect of rapamycin in mild traumatic brain-injured rats ensuing in the upregulation of autophagy and mitophagy." in: Cell biology international, Vol. 41, Issue 9, pp. 1039-1047, (2018) (PubMed).

Zhang, Gu, Chen, Ni, Hung, Wang, Zhang, Feng, Ji: "High expression of PINK1 promotes proliferation and chemoresistance of NSCLC." in: Oncology reports, Vol. 37, Issue 4, pp. 2137-2146, (2017) (PubMed).

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1 (PARK6) (PINK1 Produkte)

Synonyme: BEST:GH23468 antikoerper, CG4523 antikoerper, Dmel\\CG4523 antikoerper, PINK antikoerper, PINK1 antikoerper, dPINK1 antikoerper, dPink1 antikoerper, pink1 antikoerper, wu:fc39e12 antikoerper, zgc:101729 antikoerper, BRPK antikoerper, PARK6 antikoerper, 1190006F07Rik antikoerper, AU042772 antikoerper, AW557854 antikoerper, mFLJ00387 antikoerper, PTEN-induced putative kinase 1 antikoerper, PTEN induced putative kinase 1 antikoerper, Pink1 antikoerper, PINK1 antikoerper, pink1 antikoerper

Hintergrund: Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molekulargewicht: 62769

Gen-ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagie