ALS2 Antikörper (C-Term)

Produktnummer ABIN390394

Produktdetails anti-ALS2 Antikörper

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Bindungsspezifität: AA 1248-1277, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1248-1277 amino acids from the C-terminal region of human ALS2.

Klon: RB18853

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu ALS2

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Andere Bezeichnung: ALS2 (ALS2 Produkte)

Synonyme: als2 antikoerper, si:dkey-33m14.1 antikoerper, ALS2CR6 antikoerper, ALSJ antikoerper, IAHSP antikoerper, PLSJ antikoerper, 3222402C23Rik antikoerper, 9430073A21Rik antikoerper, Als2cr6 antikoerper, Alsin antikoerper, mKIAA1563 antikoerper, amyotrophic lateral sclerosis 2a (juvenile) antikoerper, alsin antikoerper, ALS2, alsin Rho guanine nucleotide exchange factor antikoerper, amyotrophic lateral sclerosis 2 (juvenile) antikoerper, als2a antikoerper, CpipJ_CPIJ008258 antikoerper, CpipJ_CPIJ008260 antikoerper, ALS2 antikoerper, Als2 antikoerper

Hintergrund: ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.

Molekulargewicht: 183634

Gen-ID: 57679

NCBI Accession: NP_001129217, NP_065970

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development